The US Department of Health and Human Services (HHS) announced that Secretary Robert F. Kennedy, Jr. has directed HHS to increase resources dedicated to curbing the harmful practice of information blocking. HHS will take an active enforcement against healthcare entities that restrict patients’ engagement in their care by blocking the access, exchange, and use of electronic health information. The 21st Century Cures Act of 2016 authorized the Office of the Assistant Secretary for Technology Policy/Office of the National Coordinator for Health IT (ASTP/ONC) and HHS Office of Inspector General (OIG) to take enforcement actions to hold those who block patient information accountable and to prevent future violations. As a result, ASTP/ONC, the principal federal entity charged with coordination of nationwide efforts to implement and use the most advanced health information technology, and the OIG, the primary investigative division of HHS, will play leading roles in this initiative.